A Study done at the Yonsei University in Seoul, Korea, found that the active ingredient in Ginger, [6]-Gingerol, when administered in vitro to human cancer cells, inhibited the proliferation of cells by VGEF, a signaling protein involved in the growth of cancer cells. VGEF, or Vascular Endothelial Growth Factor, has been found to play a central role in the proliferation of cancer cells. VGEF acts along two cell growth pathways, the more significant of which is the
angiogenesis pathway
, or the attachment of cells to blood vessels
. Research has found that when cells are deficient in oxygen, then the release of VGEF is stimulated. Cancerous growths are associated with higher levels of VGEF; thus, some scientists believe that oxygen deficiency lies at the root of cancerous growths.
Currently, a great deal of research is focused on inhibiting angiogenesis in cancer cells by controlling the release of VGEF, and mediating its interaction with other factors in the pathway. If the action of VGEF can be better understood and successfully controlled then this may prove to be an effective means of controlling (and destroying) cancers. VGEF also plays a role in Age-related Macular Degeneration (AMD).
In the Yonsei study, the effect of administration of [6]-Gingerol on VGEF production and the related growth of cancer cells was examined, in particular. [6]-Gingerol was found to have a significant effect on VGEF, particularly in limiting cancerous growth in rats. In the in vitro study of human cells, it was found to inhibit VEGF-induced proliferation of cancer cells. Thus, the naturally occurring flavonoid, related to capsaicin may have promise as an anti-cancer agent for certain types of cancers.
read more about the study...